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LEQVIO® (inclisiran) injection 284 mg/1.5 mL

Only LEQVIO® is HCP-administered, with 2 doses a year* for reducing LDL-C1

2 initial doses, then 2 doses a year1

Initiation of Treatment: Initial dose – Another dose at 3 months. Maintenance Treatment: Every 6 months.
  • No dose adjustments
  • No refrigeration1
  • Single-dose prefilled syringe1
  • Shelf life of 3 years2†
  • No required post-injection–related safety monitoring

Remember: Do not remove the needle cap until you are ready to inject.

For more information on administration, see the Instructions for Use Flash Card.

*After 2 initial doses and taken with statin therapy.1
Always check the expiration date on the prefilled syringe before administration.

Once administered, no chance of a missed dose for 6 months1*

HCP-administration gives you confidence your patients received their dose.

LEQVIO® (inclisiran) maintenance doses 2 doses a year* HCP-administered. Evolocumab 140mg every 2 weeks, 26 doses a year, self-injections.

Alirocumab is dosed every 2 weeks (75 mg-150 mg), equating to 26 injections/year.4 The monthly dose of PCSK9 mAbs is administered by giving 2 or 3 injections consecutively, which equates to 24 to 36 injections/year.3,4 
This is not a complete list of all the available treatments to patients with primary hyperlipidemia. 
The comparison pertains only to difference in dosing and administration and should not be considered a comparison of efficacy or safety.  

*After 2 initial doses and taken with statin therapy.1

LEQVIO administration and additional dosing information

LEQVIO® (inclisiran) product

Not actual size. 
27 gauge, 1/2-inch needle.5

  • LEQVIO is a subcutaneous injection that can be given by any state-certified HCP1
  • LEQVIO is administered into the abdomen, upper arm, or thigh1
  • Do not remove the needle cap until you are ready to inject1

For more information on administration, see the Instructions for Use Flash Card.

Missed doses

Missed doses < 3 months

Missed doses > 3 months

If a planned dose is missed by less than 3 months, administer LEQVIO and maintain dosing according to the patient’s original schedule1

If a planned dose is missed by more than 3 months, start a new dosing schedule—administer initially, again at 3 months, and then every 6 months1

In-office administration of LEQVIO:1

  • Adds minimal burden to your patient’s existing medication and care regimen 
  • Reduces LDL-C without adding another daily treatment 
  • May integrate seamlessly into your patient’s health care routine

For more information on administration, see the Instructions for Use Flash Card.

What do you need to know about LEQVIO dosing

Learn more about LEQVIO administration including injection instructions and key product information.

There's more to know about LEQVIO

Explore the LEQVIO mechanism of action

LDL-C, low-density lipoprotein cholesterol; mAb, monoclonal antibody; MOA, mechanism of action; PCSK9, proprotein convertase subtilisin/kexin type 9.

References: 1. Leqvio. Prescribing information. Novartis Pharmaceuticals Corp. 2. Data on file. LEQVIO 3-year shelf life. Novartis Pharmaceuticals Corp; 2022. 3. Repatha. Prescribing information. Amgen Inc. 4. Praluent. Prescribing information. Regeneron Pharmaceuticals Inc. 5. Data on file. LEQVIO container closure system. Novartis Pharmaceuticals Corp; 2022.